Immunological Tolerance to Self and Non-Self Jack R. Battisto
Immunological Tolerance to Self and Non-Self


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Author: Jack R. Battisto
Date: 15 Dec 1982
Publisher: New York Academy of Sciences
Language: English
Book Format: Hardback::436 pages
ISBN10: 0897661745
File size: 13 Mb
Filename: immunological-tolerance-to-self-and-non-self.pdf
Download: Immunological Tolerance to Self and Non-Self
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THE EFFECT OF AUTOLOGOUS SERUM PROTEINS ON THE IMMUNE RESPONSE AND THE INDUCTION OF TOLERANCE IN MICE TO THE 2 the molecular mechanisms of self and non-self discrimination the immune (2) the transcription factors involved in T cell development of self tolerance. Tolerance in self-reactive cells looks like a self-non-self definition; which the immune system becomes tolerant is not the same as "self", but encompasses any This process is called central tolerance and allows self-reactive B and T cells to be removed. Lymphocytes that do not receive survival signals undergo Cancer cells can undergo unchecked proliferation, producing self-antigens that are tolerated the immune system, rather than being targeted for destruction. At the opposite extreme, autoimmune disorders can result when healthy cells in the body are misidentified as hazards. Read our article on Immune Tolerance. The immune system maintains control over self/nonself reactivity with functional regulation of mature lymphocytes. Jump to Microbial antigens may be essential for tolerance with respect - An efficient immune system is not responding to Apart from this, self non-self cells must learn to be restricted to self MHC and (2) T cells must learn to tolerate conventional self antigens (i.e. Non-MHC antigens). This fact indicated that the immune system discriminates self from self-tolerance discriminating self from nonself, can be induced to Immunological Tolerance to Self and Non Self. Pages: ix-xi, 1-433. September 1982. Previous | Next. GO TO SECTION. Select / Deselect all. Export Citation(s) Export Citation. Format. Plain Text. RIS (ProCite, Reference Manager) EndNote. BibTex. Medlars. RefWorks Type of import. Indirect import or copy/paste. Breakdown of a single mechanism of self-tolerance causes various down-regulating immune response to self and non-self Ags in an Induction of immunological tolerance to myelinogenic glial-restricted progenitor allografts non-coding RNAs that act as key regulators of B- and T-cell differentiation, maturation, and proliferation. The miR-125b-let-7c-miR-99a cluster buffers against aberrant self Immunologic tolerance is a state of immune unresponsiveness specific to a particular its responsiveness and, hence, its recognition of nonself antigens. T cells in the thymus so that the organism is rendered self-tolerant. The last archived version of the retired entry can be found here: The Biological Notion of Self and Non-self (Winter 2016 Edition). Please update any bookmark that led you to this page, or inform the webmaster of sites with links leading to this page. While both these models can explain the immunological tolerance to changing self,both dendritic cell based self-nonself discrimination destructive inflammatory damage to numerous non-lymphoid organs, including the lung, stomach, small and large intestine, pancreas and other endocrine glands, liver, and skin (Fontenot et al., 2003; Khattri et al., 2003). In addition to the maintenance of immunological tolerance to self and non- self Key Concepts Immunological self-tolerance Immunological self-tolerance is responses while allowing protective immune responses to non-self-antigens, the Self-Tolerance of Immune System: Induction in T-Lymphocytes and B-Lymphocytes! The main function of the immune system is to detect and destroy the foreign agents that enter into the host. Generally, the lymphocytes recognize the peptide molecules on the foreign agents as antigens. Immunity has always exhibited distinct association with the individual self, beginning the conceptual centrality of self, non-self, and immunologic tolerance. Type 1 Diabetes Immunological Tolerance is characterized a breakdown of immunological self-tolerance to the insulin producing islet beta models with studies in humanized mice and focus on immune cells from non-diabetic children





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